Apiguard is a thymol based miticide which is suitable for natural use. It is as easy as removing the foil lid and placing the container on top of the frames in your hive. After two weeks, remove the first container and apply a second dose for another two weeks. Apiguard should be used between 60-100 degrees, and the warmer it is, the better it will work. Thymol vapors are heavier than air so make sure all entrances are fully open to allow sufficient airflow during treatment. This product is not approved for use with honey supers. The 10 pack of Apiguard will treat 5 hives. Treatment is not recommended unless you know that your varroa mite count in excess of the treatment threshold.